Chonluten (T-34) (20mg)

Chonluten (T-34) Peptide

Chonluten is also known as Tripeptide T-34 or EDG, due to its sequence (Glu-Asp-Gly). It is a cytogenetic complex consisting of short peptides that are suggested to normalize the mucous membrane cells of the lungs and the bronchial tube. It is a gene regulator associated with inflammation and antioxidant activity, and is considered to be involved in proliferation responses.^[1] It appears to function in animal test models as an anti-inflammatory in the lungs, normalizing the mucosal functions of the lungs in conditions like asthma and chronic obstructive pulmonary disease (COPD).

Specifications

Molecular Formula: C₁₁H₁₇N₃O₈

Molecular Weight: 319.27g/mol

Components: Peptide complex AC-7, microcrystalline cellulose, raw sugar, milk sugar (lactose), potato starch and twin-80

Chonluten (T-34) Research

Chonluten Peptide and Bioregulation

Research studies have proposed that various di- and tri-peptides may play a role in decelerating cellular aging. These peptides are investigated for their potential to suppress oncogenes — genes associated with abnormal growth and the development of spontaneous and induced tumors. Such tripeptides may also contribute to the regulation of gene expression, including their involvement in cellular processes such as apoptosis. According to Dr. Khavinson, Chonluten and several other short peptides may bind to DNA and exert their potential biological effects through this interaction.[3]

Chonluten Peptide and Lungs

Research has explored changes in lung tissue activity and alterations in DNA expression that may normalize the mucosal tissue of the bronchi through the apparent action of Chonluten.[2] According to Avolio et al., peptides such as Chonluten may “cooperate as natural inducers of TNF tolerance in monocytes, and act on macrophages as anti-inflammatory molecules during inflammatory and microbial-mediated activity.” Studies suggest the peptide may confer protection irrespective of infectious or non-infectious etiology and may help maintain respiratory system function in laboratory test models. Within lung tissue, Chonluten appears to regulate genes including c-Fos, heat shock protein gene HSP70, SOD, COX-2, TNF-alpha, and genes within the antioxidant system. The c-FOS protein is recognized as a regulator of cell proliferation, survival, and differentiation, appearing most active under conditions such as hypoxia and cellular destruction — with its effects potentially manifesting as thickening of the bronchial mucosal wall. The potential of Chonluten to modulate c-FOS activity may contribute to favorable pathophysiological changes in asthma and COPD. Experimental studies in test models presenting with chronic bronchitis incorporating an asthmatic component appeared to demonstrate a reduction in coughing episodes and asthmatic attacks, alongside decreased sputum production — collectively indicating an overall attenuation of the inflammatory and bronchospastic features of the condition.

Chonluten and the Gastrointestinal Tract

Chonluten has been closely examined in the context of the gastrointestinal tract (GIT). One study investigated the potential role of Chonluten in influencing mRNA expression of various genes in murine models with induced peptic ulcers, with the peptide proposed to be involved in modulating the synthesis of superoxide dismutase (SOD), TNF-alpha, and Cox-2 mRNA. SOD is characterized as an enzyme that may catalyze the dismutation of superoxide into oxygen and hydrogen peroxide — a process considered crucial in cellular defense against reactive oxygen species. TNF-alpha is broadly recognized as a cell signaling protein, or cytokine, potentially involved in systemic inflammation and regarded as part of the immune system’s acute phase response. Cox-2, in turn, is proposed as an enzyme potentially responsible for the formation of prostanoids — including prostaglandins, prostacyclin, and thromboxane — which may each play roles in the inflammatory process.[4]

Chonluten and the Pulmonary System

Research indicates that the tripeptide may potentially enhance physical performance indices and help restore the functional state of the organism toward normal levels when exposed to conditions of reduced oxygen partial pressure.[5] This suggests that the Chonluten tripeptide may improve functional capacity under hypoxic conditions. The study also appears to indicate that Chonluten may support pulmonary function in murine models of chronic bronchitis incorporating an asthmatic component. The proposed stress-protective action of Chonluten appears to be associated with its capacity to regulate the expression of specific genes — including the c-Fos gene, involved in cell proliferation and survival; the heat shock protein gene HSP70, understood to help shield cells from stress-induced damage; genes encoding antioxidant system enzymes such as SOD and COX-2, associated with protection against oxidative damage; and the tumor necrosis factor gene TNF-alpha, implicated in inflammation and immune response regulation. These observations suggest that Chonluten may influence these diverse biological processes in a manner consistent with a broad stress-protective effect.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

References