N-Acetyl Selank (10mg)

N-Acetyl Selank Peptide

N-Acetyl Selank is an acetylated form of the Selank peptide. The acetylation of the peptide into N-Acetyl Selank appears to improve its stability. Selank is a synthetic analogue of the natural tetrapeptide Tuftsin. Tuftsin is an immunomodulatory peptide, and N-Acetyl Selank appears to share many of its potential functions. In addition, N-acetyl Selank also appears to exhibit an impact on neurotransmitters, brain signaling, and neuroplasticity.

Specifications

Molecular Formula: C₃₃H₅₇N₁₁O₉

Molecular Weight: 751.9 g/mol

Sequence: AC-THR-LYS-PRO-ARG-GLY-PRO

N-Acetyl Selank Research

N-Acetyl Selank as a Nootropic

N-Acetyl Selank is suggested to share similar potential with Selank, with the added possibility of enhanced chemical stability. In research studies involving rat subjects, scientists propose that the peptide may activate serotonin metabolism in the brains of tested animals.[1] As a result, Selank exposure appeared to improve memory storage processes relative to placebo. Researchers have also clinically investigated the potential of Selank when introduced alongside a control compound in models of anxiety-phobic, hypochondriac, and somatoform disorders.[2] Compared to the control compound administered alone, the combination of Selank and the compound appeared to augment the overall effect of the control compound.

N-Acetyl Selank as an Anxiolytic

The anxiolytic potential of Selank has been examined in experimental settings. Laboratory research proposed that Selank may increase levels of calming neurotransmitters such as serotonin in rat brains.[4] Serotonin is a primary target of most anxiolytic compounds, with inhibition of its reuptake representing a common mechanism of action in this class. Additional clinical research comparing the effects of Selank and a control compound in models of generalized anxiety disorder (GAD) and neurasthenia reported that the anxiolytic impact of both the peptide and the compound were broadly comparable, though Selank appeared to demonstrate additional antiasthenic and psychostimulant potential.[5] Researchers noted that those “with GAD and neurasthenia had decreased levels of tau(1/2) leu-enkephalin, which was correlated with disease duration, severity of symptoms related to anxiety and asthenia, and autonomic disorders.” Selank appears to exert an inhibitory effect on enkephalin-degrading enzymes, considered likely to represent the primary mechanism underlying its proposed anxiolytic activity.[6]

N-Acetyl Selank and Neuroplasticity

N-Acetyl Selank may upregulate brain-derived neurotrophic factor (BDNF) levels within the central nervous system. Animal studies suggest that Selank exposure may increase BDNF concentrations in the hippocampus.[7] BDNF is a growth factor in the brain recognized for supporting neuronal growth and adaptive capacity.[8] Scientists propose that BDNF may also drive remodeling of nerve tissue and the formation of new synaptic connections.[9] BDNF may additionally stimulate neurogenesis — the formation of new neurons — potentially contributing to improved cognitive flexibility and resilience.

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References